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Save the date: HUPO-PSI Spring Meeting 2027

The next HUPO-PSI Spring Meeting, our yearly in-person event, will take place April 6-9, 2027 in Antwerp, Belgium. Organized by Wout Bittremieux, the event is hosted at the beautiful 16th-17th century site Hof van Liere in the heart of the city center. The event will kick-off with an educational day, followed by parallel discussion sessions led by all HUPO-PSI Working Groups. Save the date!

Advertisement slide for the HUPO-PSI Spring Meeting 2027. On the left, the text: HUPO-PSI Spring Meeting 2027 6–9 April 2027 Antwerp, Belgium Learn about PSI standards at the educational day Join the working group discussions Present your work with a poster Save the date www.psidev.info On the right, six pictures from the venue, location, and the previous spring meeting.

New Working Group: Making Proteomics AI-Ready

The HUPO-PSI AI-readiness Working Group has launched, bringing together researchers to make public proteomics data more usable for AI through better metadata, formats, and reprocessing workflows. Chaired by Tine Claeys, with co-chairs Samuel Wein and Ralf Gabriels, the group welcomes anyone interested in shaping practical, community-driven solutions. Get involved and follow our progress!

Documents in progress and new documents

  • The mzQC format, a data standard for reporting and exchanging quality-related information in biological mass spectrometry, has been been released on February 21st, 2024
  • The mzIdentML 1.3.0 specification and its crosslinking extension have been released on July 4th, 2024.
  • The mzPAF (Peak Annotation Format – Peptides) specification has been released on September 22nd, 2025. An edited version of  the mzPAF (Peak Annotation Format – Peptides) has been released on May 7th, 2026.
  • The mzSpecLib specification, a formal standard and file format to store and distribute spectral libraries, has been released on September 22nd, 2025
  • The FeatureTab, an exchange format for molecular interactions features, has been released on January 8th, 2026.
  • The Proforma 2.1 specification (Proteoform and Peptidoform Notation) has been released on June 21th, 2026.
  • The MIDAP (Minimum Information Describing a Proteoform) document v.1.0.0 is under revision after the external and public review phase that ended on April 19th, 2026.
  • The recommendation for encoding data independent acquisition, ion mobility data, subsampled data arrays, and additional compression types in mzML 1.1 (https://www.psidev.info/mzml) is under public and external review until September 12th. Please participate and send comments to sylvie.ricard-blum :at: univ-lyon1.fr.

See more details on these documents in progress.

HUPO-PSI Working groups and Outputs

The HUPO Proteomics Standards Initiative defines community standards for data representation in proteomics and interactomics to facilitate data comparison, exchange and verification.

Working Groups Guidelines v. Formats v. Controlled Vocabularies v.
Molecular Interactions Group charter MIMIx 1.1.2 PSI-MI XML 2.5.4 PSI-MI CV 2.5.0
MIABE 1.0.0 PSI-MI XML 3.8.8
MIAPAR 1.0.0 MITAB 2.8
FeatureTAB 1.0
Mass Spectrometry Group charter Proteomics Informatics Group charter Mass spectrometry (MIAPE-MS) 2.98 mzML 1.1.0 PSI-MS 4.1.248
Identification (MIAPE-MSI) 1.1 TraML 1.0.0 XLMOD 1.5.3
Mass spectrometry Quantification (MIAPE-Quant) 1.0 mzData† NA
mzIdentML 1.3.0
mzQuantML† 1.0.0
mzTab 1.0.0
mzTab-M 2.0.0
proBed 1.0.0
proBAM 1.0.0
PEFF 1.0.0
USI 1.0.0
SDRF‑Proteomics 1.0.0
mzSpecLib 1.0.1
mzPAF 1.0.1
ProForma 2.1.0
Protein Modifications Group charter PSI-MOD 1.033.0
Quality Control Group charter mzQC 1.0.0
Disordered Proteins Group charter Minimum Information About Disorder Experiments (MIADE) 1.0
Protein Separation (Inactive) Gel electrophoresis (MIAPE-GE) 1.4 GelML 1.1.0 sepCV 1.0.0
Gel informatics (MIAPE-GI) 1.0 spML 1.0.0
Column chromatography (MIAPE-CC) 1.1
Capillary electrophoresis (MIAPE-CE) 0.9.3
Phosphoproteomics (MIASSPE) 0.9
AI-readiness Group charter – – – – – –
Metabolomics Group charter – – – – – –
†deprecated, * in development